|
KMID : 0370220110550060441
|
|
Yakhak Hoeji
2011 Volume.55 No. 6 p.441 ~ p.445
|
|
|
Synthesis of 8-Aryloxycaffeines and Their Inhibitory Activities on Topoisomerase II
|
|
Rahman A.F.M.Motiur
Jahng Yurng-Dong
|
|
|
Abstract
|
|
|
|
A series of 8-(substituted)aryloxy- and 8-alkyloxy-caffenines were prepared from 8-bromocaffeine and (substituted) phenols as well as alkanols by Ullmann reaction and their inhibitory activities on topoisomerase II were evaluated. A compound, 8-(quinolin-2-yl)oxycaffeine showed the strongest inhibitory activity against topoisomerase II.
|
|
|
KEYWORD
|
|
|
caffeine, 8-bromocaffeine, 8-aryloxycaffeine, Ullmann reaction, topoisomerase II
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|